Cancer and conditions predisposing to cancer

In studies of cancer, only the Cancer category should be used - do not code for the site.

This is in line with the coding guidance to assign health categories based on the main disease - not pathogenesis or site of action.

However if the research involves studying a condition that predisposes to cancer, it may be appropriate to also code for the condition

e.g.g studies of Barrett's oesophagus in relation to cancer would be 50% Oral and 50% Cancer

e.g. studies of pathogens and their association with the development of cancer, such as Human Papilloma Virus (HPV) or Helicobacter pylori, should be coded 50% Infection and 50% Cancer

Studies of the normal role of oncogenes and tumour suppressor genes in a non diseased cell may be coded as 50% Generic and 50% Cancer.

Cancer is not a 'normal' process and hence studies that specifically relate to the cause of cancer are rarely coded within the 1 Underpinning code group.

In particular studies of abnormal cell cycle or DNA repair in relation to cancer should not be coded within the 1 Underpinning code group.

Studies of the normal role of oncogenes and tumour suppressor genes in a non diseased cell may be coded as 50% 1.1 Biological and 50% 2.1 Endogenous risks.